1616—1620: New England infections epidemic Affected Southern New England, British North America, especially the Wampanoag people, and killed an estimated 30% to 90% of specific populations.
Unknown source, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D
2
1633
1633—1634: Massachusetts smallpox epidemic Made about 1,000 victims
3
1634
1634—1640: Wyandot people epidemic of infections Killed between 15,000 and 25,000 Wyandot people of North America.
4
1637
1637—1637: London plague epidemic Bubonic plague epidemic in London and Westminster, England - Killed about 10,000 people